Publication date: Available online 18 April 2019Source: NeuronAuthor(s): Li-Feng Jiang-Xie, Luping Yin, Shengli Zhao, Vincent Prevosto, Bao-Xia Han, Kafui Dzirasa, Fan WangSummaryHow general anesthesia (GA) induces loss of consciousness remains unclear, and whether diverse anesthetic drugs and sleep share a common neural pathway is unknown. Previous studies have revealed that many GA drugs inhibit neural activity through targeting GABA receptors. Here, using Fos staining, ex vivo brain slice recording, and in vivo multi-channel electrophysiology, we discovered a core ensemble of hypothalamic neurons in and near t...
Source: Neuron - Category: Neuroscience Source Type: research
CONCLUSIONS: Prophylactic treatment of vancomycin 15 mg·kg infused>1 hour with 12-hour redosing and cefazolin 30 mg·kg infused>10 minutes with 4-hour redosing will maintain serum levels of each antibiotic above the susceptibility cut-offs for susceptible staphylococci in infants undergoing cardiac surgery. Cefazolin levels may be adequate for some, but not all, Gram-negative bacteria. The effect of cardiopulmonary bypass on pharmacokinetics is negligible.
PMID: 30995208 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Ingrande J, Gutierrez K, Lemmens HJ, Verma A, Nicolau DP, Sutherland CA, Ramamoorthy CTags: Anesth Analg Source Type: research