Phenols and diketopiperazines isolated from Antarctic-derived fungi, Penicillium citreonigrum SP-6

Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jia-ning Huang, Qingbo Zou, Jun Chen, Si-han Xu, Dan Luo, Feng-guo Zhang, Yuan-yuan LuAbstractOne diketopiperazine (1) and three phenols (3, 5 and 6) were isolated from static culture of Antarctic fungus, Penicillium citreonigrum SP-6, as well as their structures were determined by NMR and CD spectroscopic methods. Additionally, two known compounds, cyclo-(L-Trp-L-Phe) (2) and (-)-(3S, 10R)-dichlorodiaportal (4), were isolated and identified. Antitumor biological studies demonstrated that compounds 1 and 3 showed weak inhibitions against HCT116 cancer cell lines with IC50 values of 26.7 and 46.3 μM, respectively, comparing to cis-dichlorodiamine platinum.Graphical abstractFour new compounds were isolated from Penicillium citreonigrum SP-6 and their structures were determined by NMR and CD spectroscopic methods. Compound 1 showed weak inhibition against HCT116 cancer cell line.
Source: Phytochemistry Letters - Category: Chemistry Source Type: research