Protocatechuic acid mitigates adriamycin-induced reproductive toxicities and hepatocellular damage in rats

AbstractAdriamycin (ADR) is an anticancer drug that has a wide report of toxicity in various organs including testes and liver. This has brought limitation to its use in chemotherapy. Protocatechuic acid (PCA) is a phenolic acid   present in several  foods  of  plant origins. The aim of this study is to assess the possible action of PCA in ADR-induced reproductive and hepatic toxicities in rats. Thirty adult male rats of about 160–180 g in weight were separated into five groups: group 1 was given normal saline and se rved as control group, group 2 was administered 20 mg/kg of ADR intraperitoneally, groups 3 and 4 were administered ADR and separate doses of PCA (10 and 20 mg/kg body weight) respectively, while the group 5 rats received only 20 mg/kg of PCA. Pre-treatment with PCA significantly improved sperm m otility, sperm count, and viability in ADR-induced rats. Furthermore, elevated levels of testes and liver malondialdehyde were significantly reduced in rats treated with PCA. Also, the increased serum alkaline phosphatase, aspartate transaminase, total cholesterol, triglyceride total protein, and al bumin levels in ADR-induced rats were brought near the control value by PCA treatment. Conversely, reduction in the levels of testes and liver glutathione as well as the serum high-density lipoprotein (HDL) cholesterol level in ADR group was significantly raised in PCA-treated rats. Therefore, PCA m ay represent a natural and prom...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC05691B, CommunicationYouchao Wang, Nana Tian, Chao Li, Yuanjun Hou, Xuesong Wang, Qianxiong Zhou Incorporation of 7-dehydrocholesterol instead of cholesterol can efficiently enhance the anticancer activity of photosensitizer-encapsulated liposomes upon irradiation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Abstract Cholesterol (CHOL) is an indispensable component of liposomes. Incorporation of 7-dehydrocholesterol (7-DHC) instead of CHOL can efficiently enhance the anticancer activity of photosensitizer-encapsulated liposomes upon irradiation, yielding an IC50 value about half of that of CHOL-based controls. The photo-oxidation of 7-DHC into its endoperoxide form by singlet oxygen may account for the enhanced therapeutic effect, realizing an efficient combination of photodynamic therapy (PDT) and photoactivated chemotherapy. PMID: 31696872 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research
In this study, we investigated the combinational effects of lovastatin and TMZ on treating U87 and U251 GBM cell lines. Cytotoxicity was measured by MTT and colony formation assays; apoptosis was measured by flow cytometry; the cellular autophagic function was detected by the EGFP-mRFP-LC3 reporter and western blot assay. The results showed that lovastatin might enhance the cytotoxicity of TMZ, increase the TMZ-induced cellular apoptosis, and impair the autophagic flux in GBM cells. Lovastatin triggered autophagy initiation possibly by inhibiting the Akt/mTOR signaling pathway. Moreover, lovastatin might impair the autopha...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
ConclusionsHigh TG was a major risk factor of DIC and DS in APL treatment. It is possible that TG metabolic pathway will be linked to DIC and DS pathogenesis. Low fat diet or hyperlipidemia treatment may decrease DIC and DS progression.Legal entity responsible for the studyThe author.FundingHas not received any funding.DisclosureThe author has declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: While showing an increase in overall survival in patients with advanced lung cancer, the results of this study did not reach statistical significance. This could be due for the small sample size of this retrospective study. PMID: 31450911 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Lung cancer is the most common cancer worldwide. It also has the highest malignancy-associated mortality rate. Treatment options are limited by cancer and tumor heterogeneity, resistance to treatment options, and an advanced stage at time of diagnosis, all of which are common. Statins are a class of lipid-lowering medications that have been studied for their antitumor effects in various types of cancers. Multiple mechanisms have been proposed to explain their observed off-target effects. Most of these hypotheses focus largely on statin-induced upregulation of proapoptotic signaling pathways and mediators, and the downregul...
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Review Articles Source Type: research
Anthracycline (doxorubicin) and trastuzumab treatments for cancer patients have been known to cause cardiotoxicity. The current recommendations for prevention of cardiac events from cancer chemotherapies are largely based on opinion. The American Society of Clinical Oncology recommends active screening and prevention of modifiable cardiovascular risk factors. The risk factors are defined as tobacco use, high blood pressure, high cholesterol, alcohol use, obesity, and physical inactivity. Beta-adrenergic blockers and angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs) have been the mainstay o...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Acute myeloid leukemia (AML) is a malignant, hyperproliferative neoplasm. Since its inception, chemotherapy and hematopoietic stem cell (HSC) transplantation have substantially improved the outcome of AML, but high rate of relapsed and refractory (R/R) AML remain the major obstacles in clinical treatment. As cholesterol metabolism supplies tumor cells with necessary intermediate products and greatly influences the pathogenesis and prognosis of AML. Cholesterol abnormal it, was found between AML CR and R/R patients, and HMGCS1, a critical gene acting in cholesterol synthesis, was supposed to contribute to this phenomenon.
Source: Experimental Hematology - Category: Hematology Authors: Tags: 3159 Source Type: research
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