VA, IBM Watson Health extend precision cancer partnership

The Department of Veterans Affairs and IBM Watson Health have announced a one-year extension to an ongoing public-private partnership applying the AI company ’s technology to genomic data for cancer therapy.
Source: mobihealthnews - Category: Information Technology Source Type: news

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Authors: Davis HW, Vallabhapurapu SD, Chu Z, Vallabhapurapu SL, Franco RS, Mierzwa M, Kassing W, Barrett WL, Qi X Abstract Normal living cells exhibit phosphatidylserine (PS) primarily within the intracellular leaflet of the plasma membrane. In contrast, viable cancer cells have high levels of PS on the external surface, and exhibit a broad range of surface PS, even within specific types of cancer. Agents that target surface PS have recently been developed to treat tumors and are expected to be more effective with higher surface PS levels. In this context, we examined whether surface PS is increased with irradiatio...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Bioconjugate ChemistryDOI: 10.1021/acs.bioconjchem.9b00028
Source: Bioconjugate Chemistry - Category: Biochemistry Authors: Source Type: research
Lymphatic Research and Biology, Ahead of Print.
Source: Lymphatic Research and Biology - Category: Biology Authors: Source Type: research
About one third of primary care providers discussed breast cancer treatment decisions with their patients, a new survey shows -- but it's not really their job.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Publication date: 19 February 2019Source: Cell Reports, Volume 26, Issue 8Author(s): Deeksha Munnur, Joanna Somers, George Skalka, Ria Weston, Rebekah Jukes-Jones, Mohammed Bhogadia, Cyril Dominguez, Kelvin Cain, Ivan Ahel, Michal MalewiczSummaryAlthough poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood. NR4A nuclear orphan receptors were previously linked to DSB repair; however, their function in the process remains elusive. Classically, NR4As function as transcription factors using a specialized tandem zinc-fin...
Source: Cell Reports - Category: Cytology Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b21968
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
ConclusionsThese findings demonstrate that aesthetic treatments for side-effects of cancer therapies can alleviate perceived distress and improve skin symptoms and HRQoL.
Source: Quality of Life Research - Category: Health Management Source Type: research
ahesh Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs may cause pandemic outbreaks and zoonotic infections with, for example, highly pathogenic avian influenza virus (HPAIV) of the H5N1 and H7N9 subtypes, which pose a threat to public health. Treatment options are limited and emergence of strains resistant to antiviral drugs jeopardize this even further. Like all viruses, IAVs depend on host factors for every step of the virus replication cycle. Host kinases link multiple signaling pathways ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Publication date: Available online 18 February 2019Source: Pharmacology &TherapeuticsAuthor(s): Alexander W. Hird, Adriana E. TronAbstractDysregulation of the mitochondrial apoptotic pathway controlled by members of the Bcl-2 protein family plays a central role in cancer development and resistance to conventional cytotoxic as well as targeted therapies. Hence, selective inhibition of pro-survival Bcl-2 family of proteins to activate apoptosis in malignant cells represents an exciting anti-cancer strategy. The remarkable clinical performance of the selective Bcl-2 antagonist venetoclax has highlighted the potential for ...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 18 February 2019Source: Pharmacology &TherapeuticsAuthor(s): Viviana I. Torres, Juan A. Godoy, Nibaldo C. InestrosaAbstractCommunication between cells occurs through secreted molecules, among which Wnt ligands play a critical role in balancing cell proliferation, differentiation and cellular homeostasis. The action of Wnt signaling can be modulated at several levels, including posttranslational modification of the Wnt ligands, whose acylation is critical for biological activity. At least three enzymes are necessary for Wnt acylation/deacylation: stearoyl CoA desaturase (SCD), porcupin...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
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