How Complementary Cancer Therapies Can Increase Risk of Early Death

People diagnosed with cancer have a multitude of treatment options, many of which are standard therapies that have been well-studied to improve their chances of surviving their disease or avoiding recurrence. But people are increasingly also folding in complementary medicine approaches — which include nutrients, herbal remedies and other so-called natural supplements — with their cancer treatment regimes. While these are not nearly as well-studied as conventional therapies like surgery, radiation and chemotherapy, many people rely on them because they believe they can improve their chances of surviving their cancer or keeping recurrences at bay. In a new study published in JAMA Oncology, researchers say that may not be the case. Dr. Skyler Johnson, chief resident in therapeutic radiology at Yale School of Medicine, and his colleagues analyzed data from nearly 1,300 people in the National Cancer Database with four common cancers: breast, prostate, lung or colorectal. 1,032 of those people used only conventional medicine, and 258 used at least one conventional treatment and one or more complementary medicine strategies (which were recorded as “other unproven cancer treatments administered by nonmedical personnel”). These included IV, oral and topical therapies made up of vitamins, minerals or herbal supplements, says Johnson. Johnson found that people who added a complementary medicine approach had twice the risk of dying during the nine-year study com...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Source Type: news

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In this study, we show that DDB2 expression is downregulated in advanced HNSCCs and loss of DDB2 expression coincides with reduced survival. Recent meta-analysis of gene expression data characterized the mesenchymal-type (EMT-type) as one most aggressive cancer cluster in HNSCC. Here, we report that DDB2 constitutively represses mRNA expression of the EMT- regulatory transcription factors SNAIL, ZEB1, and angiogenic factor VEGF in HNSCC cells. As a result, re-expression of DDB2 in metastatic cells reversed EMT with transcriptional upregulation of epithelial marker E-cadherin, and downregulation of mesenchymal markers N-cad...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In the present review we will discuss the recent advances in the understanding of the role of histamine and histamine receptors in cancer biology. The controversial role of the histaminergic system in different neoplasias including gastric, colorectal, oesophageal, oral, pancreatic, liver, lung, skin, blood and breast cancers will be reviewed. The expression of histamine receptor subtypes, with special emphasis in histamine H4 receptor (H4R), in different cell lines and human tumours, the signal transduction pathways and the associated biological responses as well as thein vivo treatment of experimental tumours with pharma...
Source: British Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Purpose of review To review recent literature on health outcomes associated with use of hormonal contraception with a focus on breast cancer. Recent findings A large cohort study documented an increased risk of breast cancer among hormonal contraceptive users compared to those who had never used hormonal contraception. The overall relative risk of breast cancer among current or recent users was 1.2 [95% confidence interval (CI), 1.14–1.26]. Overall, this translates into one additional case of breast cancer for every 7690 users of hormonal contraception. Recent publications have also documented a decrease in risk...
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: FAMILY PLANNING: Edited by Paul D. Blumenthal Source Type: research
Conclusions: DOAC, warfarin, aspirin and thienopyridine use did not decrease the PPVs of the iFOBT used to evaluate all colorectal neoplasia.Digestion
Source: Digestion - Category: Gastroenterology Source Type: research
Conclusions Sulfate-based solution resulted in statistically significant better bowel cleansing compared to polyethylene glycol. Overall the excretion and completion rate was suboptimal. Achieving a high completion rate using patient-tolerable and low-risk compounds is still a challenge. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Publication date: Available online 3 November 2018Source: International Journal of PharmaceuticsAuthor(s): Eun-Ju Hyun, Mohammad Nazmul Hasan, Sung Hun Kang, Sungpil Cho, Yong-Kyu LeeAbstractOral siRNA delivery is an ideal way to translate siRNA therapeutic effects in the clinic due to its ability to be administered in convenient and multiple dosages. However, an effective oral delivery system requires overcoming both a hostile gastrointestinal (GI) environment and non-specific targeting. Here, an HTsRP-NC system is a new oral siRNA delivery system consisting of a siRNA/protamine (sRP) nano-complex protected by a multi-fun...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 2 November 2018Source: Journal of Cancer PolicyAuthor(s): Sanjeeva Gunasekera, Sanjeewa Seneviratne, Thiw.a Wijeratne, Christopher M. BoothAbstractSri Lanka, a small island nation in South Asia, is in the process of transition from a low-middle to an upper middle income country. With these changes, the burden of non-communicable disease has increased significantly. Cancer incidence has nearly doubled in twenty-five years. The pattern of cancer is also changing with breast, lung and colorectal cancers showing marked increased incidence compared to traditionally common cancers of the oral c...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 1 November 2018Source: Pharmacological ResearchAuthor(s): Kai-Wen Cheng, Chih-Hua Tseng, Cherng-Chyi Tzeng, Yu-Lin Leu, Ta-Chun Cheng, Jaw-Yuan Wang, Jia-Ming Chang, Yun-Chi Lu, Chiu-Min Cheng, I-Ju Chen, Yi-An Cheng, Yeh-Long Chen, Tian-Lu ChengAbstractIrinotecan (CPT-11), a first-line chemotherapy for advanced colorectal cancer, causes serious diarrhea in patients receiving treatment. The underlying mechanism has been shown that the active metabolite of CPT-11, SN-38, is metabolized to the inactive metabolite SN-38 glucuronide (SN-38 G) during hepatic glucuronidation, and subsequ...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: Since tissue weights are not usually included in recommendations for research tissue procurement or for frozen tissues stored in biorepositories, we offer this data as a practical guide to researcher acceptable tissue weights for selected sites based on a 3-year researcher request and acceptance history. PMID: 30379574 [PubMed - as supplied by publisher]
Source: Biopreservation and Biobanking - Category: Biomedical Science Tags: Biopreserv Biobank Source Type: research
This report provides a comprehensive assessment of recent tobacco-associated cancer incidence for each cancer type by sex, age, race/ethnicity, metropolitan county classification, tumor characteristics, U.S. census region, and state. These data are important for initiation, monitoring, and evaluation of tobacco prevention and control measures. PERIOD COVERED: 2010-2014. DESCRIPTION OF SYSTEM: Cancer incidence data from CDC's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology, and End Results program were used to calculate average annual age-adjusted incidence rate...
Source: MMWR Surveill Summ - Category: Epidemiology Authors: Tags: MMWR Surveill Summ Source Type: research
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