How Complementary Cancer Therapies Can Increase Risk of Early Death

People diagnosed with cancer have a multitude of treatment options, many of which are standard therapies that have been well-studied to improve their chances of surviving their disease or avoiding recurrence. But people are increasingly also folding in complementary medicine approaches — which include nutrients, herbal remedies and other so-called natural supplements — with their cancer treatment regimes. While these are not nearly as well-studied as conventional therapies like surgery, radiation and chemotherapy, many people rely on them because they believe they can improve their chances of surviving their cancer or keeping recurrences at bay. In a new study published in JAMA Oncology, researchers say that may not be the case. Dr. Skyler Johnson, chief resident in therapeutic radiology at Yale School of Medicine, and his colleagues analyzed data from nearly 1,300 people in the National Cancer Database with four common cancers: breast, prostate, lung or colorectal. 1,032 of those people used only conventional medicine, and 258 used at least one conventional treatment and one or more complementary medicine strategies (which were recorded as “other unproven cancer treatments administered by nonmedical personnel”). These included IV, oral and topical therapies made up of vitamins, minerals or herbal supplements, says Johnson. Johnson found that people who added a complementary medicine approach had twice the risk of dying during the nine-year study com...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Source Type: news

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Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and ...
Source: ScienceNOW - Category: Science Authors: Tags: Medicine, Diseases reports Source Type: news
Conclusion: Our results revealed that the COX-2 enzymes were expressed, suggesting that they play complementary roles during oral carcinogenesis. In near future researches on administration of chemoradiation therapy combined with COX-2 should be evaluated to improve therapy response.
Source: Indian Journal of Dental Research - Category: Dentistry Authors: Source Type: research
This article aims to describe treatment modalities used for the management of dermatologic toxicity among patients with mCRC who were treated with panitumumab and to assess the proportion of patients who were recommended preemptive versus reactive management strategies. METHODS: This retrospective chart review evaluated different treatment modalities and routes of administration. The modalities were categorized as prescription or over-the-counter. The timing in relation to the first dose of panitumumab was used to define preemptive versus reactive treatments. FINDINGS: In a sample of 330 patients, only 10% of pat...
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
CONCLUSION: Adapalene is not recommended as prophylaxis against acne-like rash induced by anti-EGFR therapies. PMID: 30890624 [PubMed - as supplied by publisher]
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Conclusion Particle size reduction of curcumin did not increase the concentration of curcumin in the plasma but increased its distribution in the ovaries. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Drug Research - Category: Drugs & Pharmacology Authors: Tags: Original Article Source Type: research
We report here a 31-year-old patient with metastatic colorectal cancer undergoing chemotherapy consisting of oxaliplatin and capecitabine who developed acute cerebellar syndrome during cycle 5. MRI did not show any abnormalities. We performed pharmacogenetic studies related to capecitabine including DPD deficiency and TYMS polymorphism. DPD gene mutation analysis was negative for the IVS14+1G>A mutation in the DPD gene, which accounts for 50% of the DPD deficiency alleles. However, the patient was found to have 3RG/3RC genotype and Del/Del genotype of TYMS 3′-untranslated region. Withdrawal of capecitabine improve...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: CASE REPORTS Source Type: research
Authors: Xu H, Jiang J, Zhang J, Cheng L, Pan S, Li Y Abstract Several studies have shown that microRNA-375 (miR-375) is frequently downregulated in several types of human cancer including gastric cancer, colorectal cancer and oral squamous cell carcinoma. However, the role of miR-375 in human esophageal cancer remains unknown. In the current study, the expression level of miR-375 was analyzed in 43 esophageal squamous cell carcinoma (ESCC) tissue and matched adjacent normal tissue samples from patients with ESCC by reverse transcription-quantitative polymerase chain reaction. In addition, the expression level of m...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
CONCLUSION: Apatinib monotherapy showed promising efficiency for patients with refractory colorectal cancer, especially in patients with PS 0-1 or no liver metastasis. ctDNA abundance may be a predictor in serial monitoring of tumor load. PMID: 30877190 [PubMed - as supplied by publisher]
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
ConclusionsICG-FI was associated with significantly lower odds of AL in laparoscopic LAR for rectal cancer.Clinical trialThe study was registered with the Japanese Clinical Trials Registry as UMIN000032654.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
eok Ahn Capsazepine is a synthetic analogue of capsaicin that can function as an antagonist of TRPV1. Capsazepine can exhibit diverse effects on cancer (prostate cancer, breast cancer, colorectal cancer, oral cancer, and osteosarcoma) growth and survival, and can be therapeutically used against other major disorders such as colitis, pancreatitis, malaria, and epilepsy. Capsazepine has been reported to exhibit pleiotropic anti-cancer effects against numerous tumor cell lines. Capsazepine can modulate Janus activated kinase (JAK)/signal transducer and activator of the transcription (STAT) pathway, intracellular Ca2+ conc...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
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