Molecules, Vol. 23, Pages 1776: A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections
Molecules, Vol. 23, Pages 1776: A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections
Molecules doi: 10.3390/molecules23071776
Authors:
Javier Campanini-Salinas
Juan Andrades-Lagos
Gerardo Gonzalez Rocha
Duane Choquesillo-Lazarte
Soledad Bollo Dragnic
Mario Faúndez
Pedro Alarcón
Francisco Silva
Roberto Vidal
Edison Salas-Huenuleo
Marcelo Kogan
Jaime Mella
Gonzalo Recabarren Gajardo
David Vásquez-Velásquez
A rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics and reducing the therapeutic arsenal available for treatment of infectious diseases. In the present study, we developed a new class of compounds with antibacterial activity obtained by a simple, two step synthesis and screened the products for in vitro antibacterial activity against ATCC® strains using the broth microdilution method. The compounds exhibited minimum inhibitory concentrations (MIC) of 1–32 μg/mL against Gram-positive ATCC® strains. The structure–activity relationship indicated that the thiophenol ring is essential for antibacterial activity and the substituents on the thiophenol ring module, for antibacterial activity. The most promising compounds detected by screening were tested against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF) clinical isolates....
Source: Molecules - Category: Chemistry Authors: Javier Campanini-Salinas Juan Andrades-Lagos Gerardo Gonzalez Rocha Duane Choquesillo-Lazarte Soledad Bollo Dragnic Mario Fa úndez Pedro Alarc ón Francisco Silva Roberto Vidal Edison Salas-Huenuleo Marcelo Kogan Jaime Mella Gonzalo Recabarren Gajardo Da Tags: Article Source Type: research
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