Molecules, Vol. 23, Pages 1776: A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections

Molecules, Vol. 23, Pages 1776: A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections Molecules doi: 10.3390/molecules23071776 Authors: Javier Campanini-Salinas Juan Andrades-Lagos Gerardo Gonzalez Rocha Duane Choquesillo-Lazarte Soledad Bollo Dragnic Mario Faúndez Pedro Alarcón Francisco Silva Roberto Vidal Edison Salas-Huenuleo Marcelo Kogan Jaime Mella Gonzalo Recabarren Gajardo David Vásquez-Velásquez A rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics and reducing the therapeutic arsenal available for treatment of infectious diseases. In the present study, we developed a new class of compounds with antibacterial activity obtained by a simple, two step synthesis and screened the products for in vitro antibacterial activity against ATCC® strains using the broth microdilution method. The compounds exhibited minimum inhibitory concentrations (MIC) of 1–32 μg/mL against Gram-positive ATCC® strains. The structure–activity relationship indicated that the thiophenol ring is essential for antibacterial activity and the substituents on the thiophenol ring module, for antibacterial activity. The most promising compounds detected by screening were tested against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF) clinical isolates....
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research