Gut-origin sepsis in the critically ill patient: pathophysiology and treatment

This Literature Review concludes that gut permeability is increased in critically ill patients, and is associated with the development of the systemic inflammatory response syndrome and multiple organ dysfunction syndrome (MODS). The pathogenetic link(s) and potential therapies are an area of intense research over the last decades. There is an emerging need for application of sensitive non-invasive and easily measured biomarkers of early intestinal injury (e.g., citrulline, intestinal fatty acid protein, and zonulin) in our everyday clinical practice, guiding the early pharmacological intervention in critically ill patients to restore or prevent intestinal injury and improve their outcomes.

Source: Current Awareness Service for Health (CASH) - July 19, 2018 Category: Consumer Health News Source Type: news