Palladium-catalyzed C(carbonyl)-C bond cleavage of amides: a facile access to phenylcarbamate derivatives with alcohols.

Palladium-catalyzed C(carbonyl)-C bond cleavage of amides: a facile access to phenylcarbamate derivatives with alcohols.
Chem Commun (Camb). 2018 Jul 17;:
Authors: Yan X, Sun H, Xiang H, Yu DG, Luo D, Zhou X
Abstract
A sulfur-containing auxiliary enabled palladium-catalyzed C(carbonyl)-C bond activation of amides was reported to form phenylcarbamate derivatives with alcohols. Both alkyl and benzyl alcohols could be employed well with yields up to 85%. Derivations from phenylcarbamates to ureas and thiocarbamates illustrated the potential applications of this sequential C-C cleavage/C-O coupling reaction.
PMID: 30015335 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 17, 2018 Category: Chemistry Authors: Yan X, Sun H, Xiang H, Yu DG, Luo D, Zhou X Tags: Chem Commun (Camb) Source Type: research