Raised risk of MI and mortality when starting sulfonylurea

Continuing metformin when introducing sulfonylureas in type 2 diabetes safer than switching Related items fromOnMedica Sugar not saturated fat is the major issue for CVD Experts query risks of pioglitazone Regulators suspend Avandia over safety concerns Daily aspirin use linked to major bleeding Use of DPP-4 inhibitors associated with increased risk of IBD
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Aspirin is once again in the headlines, prompted by New England Journal of Medicine reports suggesting that people aged 70 years and older obtain no benefit and perhaps experience harm in the form of increased bleeding and increased death from cancer on low-dose aspirin. This adds to the decades-long debate on whether aspirin is beneficial as a preventive measure against cardiovascular events such as heart attack in which a blood clot forms on top of inflamed atherosclerotic plaque in the coronary arteries. Unlike many other studies that are observational and therefore virtually useless, these studies are prospective and r...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates aspirin coronary grain-free heart attack heart disease Inflammation platelets Weight Loss wheat belly Source Type: blogs
We wish to share our experience with a rare case of leiomyomatosis peritonealis disseminate LPD, which is a rare condition characterized by the presence of multiple benign smooth muscle nodules located on peritoneal surfaces [1]. A 60  year postmenopausal woman had a 4 month history of abdominal bloating and postmenopausal bleeding, which required a total abdominal hysterectomy with bilateral salpingoopherectomy for a large benign uterine leiomyoma. She was para 3 with a BMI of 31 and medical history included type 2 diabetes me llitus, asthma, and rheumatoid arthritis.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Correspondence Source Type: research
GI Dynamics (ASX:GID) said today it won FDA investigational device exemption approval to launch a pivotal trial of its EndoBarrier device designed for treating patients with type 2 diabetes and obesity, pending Institutional Review Board approval. The EndoBarrier device is a plastic gut sleeve designed to prevent the absorption of nutrients from food as it exits the stomach and enters the intestinal tract to treat type 2 diabetes and obesity, the Lexington, Mass.-based company said. The approval is a boon for the company, which has faced a number of hurdles with its device over the past few years, inclu...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Diabetes Food & Drug Administration (FDA) Regulatory/Compliance Weight loss GI Dynamics Source Type: news
Abstract The aim of the present study was to compare the clinical and radiographic periodontal parameters in prediabetes, type 2 diabetes mellitus (T2DM), and non-diabetic patients. Forty-one patients with prediabetes (Group 1), 43 patients with T2DM (Group 2), and 41 controls (Group 3) were included. Demographic data were recorded using a questionnaire. Full-mouth clinical (plaque index [PI], bleeding on probing [BOP], probing depth [PD], clinical attachment loss [CAL], missing teeth [MT]) and radiographic (marginal bone loss [MBL]) parameters were measured on digital radiographs. In all groups, hemoglobin A1c (HbA1c) lev...
Source: Brazilian Oral Research - Category: Dentistry Source Type: research
Lata Goyal, Narinder Dev Gupta, Namita GuptaJournal of Indian Society of Periodontology 2018 22(3):263-265 Grinspan syndrome is a syndromic complex which comprises a triad of hypertension, diabetes, and oral lichen planus. It remains an enigmatic condition that whether it is separate entity or drug-induced lichenoid reaction emerging due to medications used to treat hypertension and diabetes. Diabetes is related to long-term hyperglycinemia leading to accelerated destruction of both nonmineralized connective tissue and bone leading to periodontitis. Moreover, there is also a possible link between cardiovascular disease an...
Source: Journal of Indian Society of Periodontology - Category: Dentistry Authors: Source Type: research
Owing to the multiple steps in coagulation and fibrinolysis, there is an increasing interest in the use of global dynamic fibrin clot lysis assays to evaluate both coagulation and fibrinolysis in the same test [1]. Thus, an increasing number of research laboratories use fibrin clot lysis assays to evaluate fibrin clot properties in different patient populations, e.g. patients with atherothrombosis, type 2 diabetes or in patients with intracranial bleeding [1,2].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research
Authors: Abstract Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding. The clinical approach to...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research
Authors: Abstract Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding. The clinical approach to...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research
Conclusion: In elective PCI, low-dose UFH with sequential enoxaparin has similar effects and safety to the UFH-only method. PMID: 29578118 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
An 82-year-old woman presented to our outpatient clinic with a 6-month history of recurrent internal bleeding near the eyes. The patient had a history of type 2 diabetes mellitus, but had no significant medical history including traumatic injuries. Physical examination revealed bilateral periorbital ecchymosis and large tongue (Figure 1). Serum protein electrophoresis revealed an M-peak in the gamma fraction, and urine immunofixation electrophoresis was positive for Bence-Jones protein. In addition, amyloid fibrils were detected in biopsy of abdominal subcutaneous fat tissue.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
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