Genome-wide identification of transcription factors that are critical to non-small cell lung cancer

To systematically unveil transcription factors (TFs) that are critical to lung carcinogenesis, here we conducted a genome-wide lethality screening in non-small cell lung cancer (NSCLC) cells and reported that among the 1530  TFs tested, 21 genes were required for NSCLC cell proliferation and were negatively or positively associated with overall survival (OS) of patients with NSCLC. These included 11 potential tumor suppressing genes (AFF3, AhR, AR, CBFA2T3, CHD4, KANK2, NR3C2, PTEN, PRDM16, RB1, and STK11) and 10 pot ential oncogenic TFs (BARX1, DLX6, ELF3, EN1, ETV1, FOXE1, HOXB7, IRX4, IRX5, and SALL1).

Source: Cancer Letters - July 18, 2018 Category: Cancer & Oncology Authors: Da-Lin Zhang, Li-Wei Qu, Liang Ma, Yong-Chun Zhou, Gui-Zhen Wang, Xin-Chun Zhao, Chen Zhang, Yan-Fei Zhang, Min Wang, Mei-Ying Zhang, Hong Yu, Bei-Bei Sun, San-Hui Gao, Xin Cheng, Ming-Zhou Guo, Yun-Chao Huang, Guang-Biao Zhou Tags: Original Articles Source Type: research