7 T MRI reveals hippocampal structural abnormalities associated with memory intrusions in childhood-onset schizophrenia

The hippocampus exhibits striking volume reductions in schizophrenia (van Erp et al., 2016), with regionally specific changes in subfields cornu ammonis 1 to 4 (CA1-4), dentate gyrus, and subiculum (Mathew et al., 2014). Models of hippocampal function suggest an association with memory deficits in schizophrenia patients; for example, impairment of the pattern separation component of declarative memory in schizophrenia suggests dentate gyrus dysfunction (Das et al., 2014). As yet, however, there is incomplete understanding of how subfield structure contributes to these impairments.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research

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DiscussionIt is feasible for those with schizophrenia to use their own smartphones to complete cognitive assessments and other measures related to their mental health. While we did not investigate the correlations between these cognitive assessments and other smartphone captured metrics like step count or self-reported symptoms, the potential to longitudinally assess cognition in the context of patients' environments outside of the clinic presents unique opportunities for characterizing cognitive burden in schizophrenia.
Source: Schizophrenia Research: Cognition - Category: Psychiatry Source Type: research
ConclusionsAutoconnectivity is cognitive state dependent (resting-state vs. task) and mental state dependent (healthy vs. schizophrenia). The concept of autoconnectivity resembles a recurrent neural network and provides a new perspective of functional integration in the brain. These findings may have important implications for understanding of brain function in health and disease as well as for analysis of fMRI time-series.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
CONCLUSIONS: Massa intermedia is present in most of the investigated brains, usually connecting the anterior-superior quadrants of the lateral walls of the third ventricle. Different in shape and size its cross-section is a horizontal ellipse, significantly larger in females. The cross-sectional area and the size of the third ventricle are not in correlation. PMID: 30993663 [PubMed - as supplied by publisher]
Source: Folia Morphologica - Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research
We report on a 38-year-old patient with adult-onset psychotic symptoms on a background of infantile-onset seizures, autistic features and episodic ataxia. Whole-exome sequencing revealed a de-novo novel SCN2A mutation (c.4966T > C, p.Ser1656Pro). This and other SCN2A mutations associated with the schizophrenia phenotype overlap those seen in neurodevelopmental disorders, suggesting a common underlying mechanism. This is the first report of a patient with the entire known SCN2A phenotypic spectrum. We highlight the importance of recognizing the psychiatric phenotypes associated with SCN2A mutations and that...
Source: Psychiatric Genetics - Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
This study aimed to characterize people with schizophrenia by comparing clinical s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news
Conditions:   Schizophrenia and Related Disorders;   Schizophrenia;   Schizoaffective Disorder;   Brief Psychotic Disorder Interventions:   Device: 1 Hz rTMS;   Device: iTBS;   Drug: Placebo Sponsor:   University of Bern Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Magnetic Resonance Imaging (MRI) can now be used in conjunction with machine learning to predict cognitive development in infants,  according to a  studyrecently published inNeuroImage.White matter is intrinsic to developing brain activity, and the white matter connectome at birth can be used as a neuroimaging biomarker to calculate cognitive development. The group of researchers led by Jessica B. Girault, PhD, from the Carolina Institute for Developmental Disabilities at the University of North Carolina Chapel Hill are searching for imaging biomarkers like white matter to determine risks for neuropsychiatric con...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Conclusion: The results suggest that MTHFR polymorphisms are unlikely to play a major role in the pathogenesis of OCD. Further studies are needed in biochemical data on folate metabolism to clarify the effect of the MTHFR polymorphisms in OCD pathophysiology. PMID: 30992611 [PubMed]
Source: Indian Journal of Psychiatry - Category: Psychiatry Tags: Indian J Psychiatry Source Type: research
We describe herein a case of an elderly man who presented with psychosis and after thorough workup was diagnosed to be a case of a NS. Schizophrenia-like psychosis as the presenting and the only manifested feature of NS in a nonhuman immunodeficiency virus-infected patient was a unusual and noteworthy feature in the present case. PMID: 30992619 [PubMed]
Source: Indian Journal of Psychiatry - Category: Psychiatry Tags: Indian J Psychiatry Source Type: research
AbstractThe connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are intracellularly degraded by fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Thus, the function of ECS might be modulated in a direct way, through CB receptor ligands or indirectly by FAAH and MAGL inhibitors. We evaluated that the direct influence of ECS, using FAAH...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
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