7 T MRI reveals hippocampal structural abnormalities associated with memory intrusions in childhood-onset schizophrenia

The hippocampus exhibits striking volume reductions in schizophrenia (van Erp et al., 2016), with regionally specific changes in subfields cornu ammonis 1 to 4 (CA1-4), dentate gyrus, and subiculum (Mathew et al., 2014). Models of hippocampal function suggest an association with memory deficits in schizophrenia patients; for example, impairment of the pattern separation component of declarative memory in schizophrenia suggests dentate gyrus dysfunction (Das et al., 2014). As yet, however, there is incomplete understanding of how subfield structure contributes to these impairments.

Source: Schizophrenia Research - July 18, 2018 Category: Psychiatry Authors: Dale Zhou, Siyuan Liu, Xueping Zhou, Rebecca Berman, Diane Broadnax, Peter Gochman, Judith Rapoport, Adam Thomas Tags: Letter to the Editor Source Type: research