BK nephropathy with glomerular involvement

A 17-year-old patient 8 months after kidney transplant presented with BK viremia of 1.1  × 106 copies/ml and serum creatinine of 0.8 mg/dl. An allograft kidney biopsy was performed, which showed extensive interstitial inflammation and viral inclusions in the tubular epithelial cells. In addition, numerous viral inclusions were seen in the glomeruli. In situ hybridization study for th e BK virus confirmed the findings and was positive for the BK virus present in the tubular epithelium, the parietal epithelium of the Bowman's capsule, shedding cells in Bowman's space and based on the location also within podocytes (Figure 1).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research