Crossloads of metabolism and  CKD

Sensitive and useful biomarkers for predicting chronic kidney disease (CKD) and its prognosis are urgently needed. Using a nontargeted metabolomic approach, Hu et  al. explored an established CKD cohort, Modification of Diet in Renal Disease, as well as a validation cohort, African American Study of Kidney Disease and Hypertension. They identified 3 serum metabolites (ribonate, fumarate, and allantoin) significantly associated with mortality in CKD even afte r statistical adjustment by multiple clinical covariates including glomerular filtration rate and urinary protein.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research