Histomorphometric Evaluation of the Ki-67 Proliferation Rate and CD34 Microvascular and D2-40 Lymphovascular Densities Drives the Pulmonary Typical Carcinoid Outcome

In this study, we sought to validate the importance of Ki-67 and study the relationships between Ki-67 and other stromal biomarkers of vascular density. We examined Ki-67, CD34 and D2-40 in tumor tissues from 128 patients with surgically excised typical carcinoid of the lung. We used immunohistochemistry and morphometry to evaluate the amount of tumor staining for cellular proliferation (Ki-67), microvascular density (CD34-MVD) and lymphovascular density (D2-40-LVD).

Source: Human Pathology - July 18, 2018 Category: Pathology Authors: Alyne Fonseca de Vilhena, Jo ão Carlos das Neves Pereira, Edwin Roger Parra, Marcelo Luiz Balancin, Alexandre A'b Saber, Vanessa Martins, Cecilia Farhat, Marcelo Militao Abrantes, Jose Ribas Milanez de Campos, Miguel Lia Tedde, Teresa Takagaki, Vera Luiz Tags: Original contribution Source Type: research