Two new triterpenoids from the stems of Celastrus orbiculatus Thunb

Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Lun Wang, Huan Tang, Kai Chen, Lin-Lin Xue, Hao-Yu Ye, Li-Fang Ma, Zi-Yuan LiAbstractTwo new triterpenoids, named as 3β-(E)-p-caffeoylnepeticin (1) and 3β-(E)-3,4-dimethoxycinnamate-20(S)-dammarenediol II (2), along with three known compounds 3, 4 and 5 were isolated from the stems of Celastrus orbiculatus Thunb. The structures of these compounds were elucidated by spectroscopic methods including IR, 1D and 2D NMR as well as by high-resolution mass spectrometric analysis. The anti-inflammatory activities and the cytotoxic effects were evaluated on lipopolysaccharide induced nitric oxide production in RAW 264.7 cells and two tumor cell lines (MCF-7 and A2780s), respectively. Results showed that compounds 1 and 3 exhibited weak anti-inflammatory activity with the IC50 value of 18.50 and 10.51 μM respectively, while all compounds were inactive in both cell lines (IC50> 20 μM).Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
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