Research identifies new breast cancer therapeutic target

(Louisiana State University Health Sciences Center) Research led by Suresh Alahari, PhD, Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has shown for the first time that a tiny piece of RNA deregulates energy metabolism, an emerging hallmark of cancer. The finding identifies a new target for therapeutic intervention in breast cancer.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusion: Our findings provide strong evidence that miR-9 and miR-221 can enhance the generation of cancer stem cells to yield an invasive phenotype and that overexpression of these miRNAs predicts a poor outcome for breast cancer patients.Cell Physiol Biochem 2018;48:2205 –2218
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Source: Breast Cancer? But Doctor....I hate pink! - Category: Cancer & Oncology Source Type: blogs
Uma Sharma, Khushbu Agarwal, Rani G. Sah, Rajinder Parshad, Vurthaluru Seenu, Sandeep Mathur, Siddhartha D. Gupta, Naranamangalam R. Jagannathan
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Rita Sanghvi Mehta, MD, UC Irvine Health, talks about SWOG S0226 - for Metastatic Breast Cancer | Additional Fulvestrant and Anastrozole Improves PFS at MOASC 2018. Author: moasc Added: 08/14/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
Abstract PURPOSE: The occurrence of upper extremity lymphedema after regional nodal irradiation (RNI) for breast cancer treatment varies significantly based on patient and treatment factors. The relationship between the radiation therapy (RT) field design and lymphedema risk is not well-characterized. The present study sought to correlate the variations in RT field design with lymphedema outcomes. METHODS AND MATERIALS: Women with stage II-IV breast cancer receiving RNI after breast surgery that included sentinel lymph node biopsy or axillary dissection were identified. Their arm circumference was measured be...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
Authors: Alexander W Abstract We review key findings in the areas of prostate cancer, non-small-cell lung cancer, breast cancer, esophageal cancer, pancreatic cancer, leukemias, metastatic colon cancer, and one session on molecular profiling guidance of therapy. PMID: 30100691 [PubMed]
Source: P and T - Category: Drugs & Pharmacology Tags: P T Source Type: research
This article describes the scope and quality of evidence related to exercise interventions to improve sleep in women with breast cancer. Fifteen studies met the criteria and 12 were judged to be excellent quality. The most frequent intervention was walking, primarily during the time of chemotherapy. Eleven studies reported postintervention improvement in sleep deficiency. Most yoga, qigong, and dance intervention studies reported no differences between groups. Emerging evidence exists for the effectiveness of aerobic exercise to improve various sleep outcomes in women with breast cancer. PMID: 30098755 [PubMed - in process]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Sleep Med Clin Source Type: research
Abstract Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given ...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Endocrinol Metab Clin North Am Source Type: research
Authors: Merino T, Ip T, Domínguez F, Acevedo F, Medina L, Villaroel A, Camus M, Vinés E, Sánchez C Abstract Background: Although fairly uncommon, loco-regional recurrence in breast cancer (BC) has major consequences for the patient. Several predictors for locoregional have been previously reported from large randomized clinical trials mainly from Europe &North America; data from other geographical areas are somewhat scarce. Here we performed a retrospective review of medical records in a single academic center in Chile, searching for predictors of breast tumor recurrence. Results: Medi...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Campbell MC, Pontiggia L, Russell AY, Schwarting R, Camacho J, Jasmin JF, Mercier I Abstract Breast cancers (BCas) that lack expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are referred to as triple negative breast cancers (TNBCs) and have the poorest clinical outcome. Once these aggressive tumors progress to distant organs, the median survival decreases to 12 months. With endocrine therapies being ineffective in this BCa subtype, highly toxic chemo- and radiation therapies are the only options. A better understanding of the function...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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