MGMT gene promoter methylation and its correlation with clinicopathological parameters in glioblastomas

Conclusions: The frequency of MGMT promoter methylation in GBMs was 49.2%, which was significantly associated with IDHR132H mutation and ATRX loss. In addition, the presence of confluent necrosis was significantly associated with MGMT unmethylation and was found to be an independent predictor of the same.

Source: Neurology India - July 18, 2018 Category: Neurology Authors: Iteeka Arora Mamta Gurav Rachna Rumde Sandeep Dhanavade Vinayak Kadam Hetakshi Kurani Omshree Shetty Jayant Sastri Goda Prakash Shetty Aliasgar Moiyadi Tejpal Gupta Rakesh Jalali Sridhar Epari Source Type: research