Estrogen receptor beta and truncated variants enhance the expression of transfected MMP-1 promoter constructs in response to specific mechanical loading

Conclusions These results suggest that the 1G/2G alleles of MMP-1 are influenced by specific mechanical stimuli like shear stress, as well as the ER-β receptor. These findings contribute to the potential allelic involvement in connective tissue diseases such as OA in females compared to males.

http://link.springer.com/10.1186/s13293-014-0014-6

Source: Biology of Sex Differences - September 27, 2014 Category: Biology Source Type: research