The Heart and the Kidney: What One Tells You about the Other

​BY AN​UMEHA SINGH, MDA 56-year-old man presented to the ED with shortness of breath and pleural effusions diagnosed by an outside treating physician. The workup included urinalysis, which showed proteinuria, and the exam was consistent with myxedema and pedal edema. He had a history of rheumatoid arthritis, leukocytoclastic vasculitis and Sjögren's syndrome, diabetes, and monoclonal gammopathy of unknown significance (MGUS).The patient also had shortness of breath for a month and pleural effusions on outpatient chest x-ray. He had taken Humira, methotrexate (MTX), and steroids, but his arthritis and Sjögren's were currently well controlled without medications. His MGUS was monitored annually with no medical intervention. He felt excessive thirst, but had normal urine output. The patient appeared well, but would not stop taking sips of water in between every sentence of a conversation despite obvious myxedema.He noted face and hand swelling that morning, which gave way to more significant pedal edema at the end of the day and progressively worsening exertional dyspnea. He noted low-grade fever and loss of appetite. His initial vitals were a blood pressure of 185/96 mm Hg, oxygen saturation of 97% on room air, heart rate of 106 bpm, respiratory rate of 20 bpm, and temperature of 100.1°F.The differential diagnoses for this case included an infectious process such as viral or bacterial infiltrate and lung mass or atypical presentation of myeloma given the patie...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research

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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
Contributors : Diane M Ward ; Alexandra SeguinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHepatocyte-specific loss of Slc25a37 (Mitoferrin1) in Mitoferrin2-/- mice did not affect animal viability or liver size suggesting that there must be alternative hepatocyte mitochondrial iron importers that function in the absence of Mitoferrins.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
The findings could have implications regarding different strategies for managing hypertension in women compared to men, the study authors suggest.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news
Authors: Barton BB, Segger F, Fischer K, Obermeier M, Musil R Abstract Introduction: Antipsychotic-induced weight-gain (AIWG) is a very important, yet often neglected side-effect in the treatment with first and second generation antipsychotics. AIWG can increase the risk of developing metabolic syndrome, diabetes and cardiovascular disease. Meta-analyses mostly concentrate on AIWG in schizophrenic and bipolar patients, even though antipsychotics are prescribed off-label across many other diagnostic groups (e.g. anxiety disorders, depression, autistic disorder).Areas covered: Pub Med and Web of Science were systemat...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Publication date: Available online 20 January 2020Source: Nano EnergyAuthor(s): Qian Cai, Wenting Hong, Chuanyong Jian, Wei LiuABSTRACTSlow charge transfer kinetics and poor stability are two critical issues for silicon (Si) photoanodes in photoelectrochemical (PEC) water splitting. Herein, a facile and ultrafast interfacial reaction was performed on n-Si/Ni for stable and high-performance Si photoanode by regulating both the Ni electrocatalyst and Si surface. The calculated and experimental results reveal that highly catalytic oxygen vacancies-rich Fe:NiOOH layer will be formed on Ni surface during the hot Fe ions exchang...
Source: Nano Energy - Category: Nanotechnology Source Type: research
Publication date: Available online 20 January 2020Source: Clinica Chimica ActaAuthor(s): Hanna AntushevichAbstractFecal microbiota transplantation (FMT) is the introduction (transplantation) of gut microbiota obtained from the faeces of a healthy donor into the patient’s gastrointestinal tract. Most often, such therapy is used the treatment of gastrointestinal diseases caused by the activity of pathogenic or conditionally pathogenic microorganisms, however, recently an increasing number of studies have reported the use of fecal microbiota transplantation for the treatment of diseases such as metabolic syndrome, diabe...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
The high saturated fat content of coconut oil could be driving adverse cholesterol changes, authors of a new review of published studies suggest.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news
Publication date: Available online 20 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Tatianna F.S. De Nardo, Paulo H.L. Bertolo, Priscila A. Bernardes, Danísio P. Munari, Gisele F. Machado, Luciana S. Jardim, Pamela R.R. Moreira, Mayara C. Rosolem, Rosemeri O. VasconcelosABSTRACTMacrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that is produced by many cell types in situations of homeostasis or disease. One of its functions is to act as a proinflammatory molecule. In humans, several studies have shown that MIF levels become elevated in the serum, urine, cerebrospinal flu...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Authors: Augstburger E, Héron E, Abanou A, Habas C, Baudouin C, Labbé A Abstract Ischemic optic neuropathies are among the leading causes of severe visual acuity loss in people over 50 years of age. They constitute a set of various entities that are clinically, etiologically and therapeutically different. Anatomically, it is necessary to distinguish anterior and posterior forms. From an etiological point of view, the diagnosis of the arteritic form due to giant cell arteritis requires emergent management to prevent blindness and even death in the absence of prompt corticosteroid treatment. When this d...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.C. Andr é Ohlin The energetics of the different spin states of the five isomers of the iron(III) Keggin ion, [Fe(O4)(Fe(OH)2(OH2))12]7+, has been investigated using density functional theory in order to demonstrate how the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
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