Intracerebroventricular streptozotocin-induced Alzheimer's disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex.

CONCLUSION: These results suggest that the reduction in GABAergic inhibition in the PBN and VLPO may be involved in sleep disorders that are induced by STZ. Our novel findings encourage further studies that investigate mechanisms of sleep regulation in sporadic AD.
PMID: 30014576 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - July 16, 2018 Category: Neuroscience Authors: Cui SY, Song JZ, Cui XY, Hu X, Ma YN, Shi YT, Luo Y, Ge YR, Ding H, Ye H, Zhang YH Tags: CNS Neurosci Ther Source Type: research