Cyclooxygenases and lipoxygenases are used by the fungus Podospora anserina to repel nematodes

Publication date: Available online 17 July 2018Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Roselyne Ferrari, Isabelle Lacaze, Pauline Le Faouder, Justine Bertrand-Michel, Camille Oger, Jean-Marie Galano, Thierry Durand, Stéphane Moularat, Laetitia Chan Ho Tong, Charlie Boucher, Jaafar Kilani, Yohann Petit, Océane Vanparis, César Trannoy, Sylvain Brun, Hervé Lalucque, Fabienne Malagnac, Philippe SilarAbstractOxylipins are secondary messengers used universally in the living world for communication and defense. The paradigm is that they are produced enzymatically for the eicosanoids and non-enzymatically for the isoprostanoids. They are supposed to be degraded into volatile organic compounds (VOCs) and to participate in aroma production. Some such chemicals composed of eight carbons are also envisoned as alternatives to fossil fuels. In fungi, oxylipins have been mostly studied in Aspergilli and shown to be involved in signalling asexual versus sexual development, mycotoxin production and interaction with the host for pathogenic species. Through targeted gene deletions of genes encoding oxylipin-producing enzymes and chemical analysis of oxylipins and volatile organic compounds, we show that in the distantly-related ascomycete Podospora anserina, isoprostanoids are likely produced enzymatically. We show the disappearance in the mutants lacking lipoxygenases and cyclooxygenases of the production of 10-hydroxy-octadecadienoic acid and that of 1-oct...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research