Sarcomeric Auto-Oscillations in Single Myofibrils From the Heart of Patients With Dilated Cardiomyopathy [Original Articles]

Conclusions: Sarcomere dynamics was found to be depressed under loaded conditions in DCM myofibrils because of impairment of thick-thin filament sliding. Thus, microscopic analysis of Ca-SPOC in human cardiac myofibrils is beneficial to systematically unveil the kinetic properties of single sarcomeres in various types of heart disease.
Source: Circulation: Heart Failure - Category: Cardiology Authors: Tags: Basic Science Research, Contractile Function, Myocardial Biology, Pathophysiology, Heart Failure Original Articles Source Type: research