Targeting Ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: lessons learned from clinical trials

The ubiquitin-proteasome pathway (UPP) is the main non-lysosomal proteolytic system responsible for degradation of most intracellular proteins, specifically damaged and regulatory proteins. The UPP is implicated in all aspects of the cellular metabolic networks including physiological or pathological conditions. Alterations in the components of the UPP can lead to stabilization of oncoproteins or augmented degradation of tumour suppressor favouring cancer appearance and progression. Polyphenols are natural compounds that can modulate proteasome activity or the expression of proteasome subunits.

Source: Cancer Letters - July 17, 2018 Category: Cancer & Oncology Authors: Seyed Fazel Nabavi, Atanas G. Atanasov, Haroon Khan, Davide Barreca, Domenico Trombetta, Lara Testai, Antoni Sureda, Silvia Tejada, Rosa Anna Vacca, Valeria Pittala, Diana Gulei, Ioana Berindan-Neagoe, Samira Shirooie, Seyed Mohammad Nabavi Source Type: research