Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides.
This study assessed the effects of artificial cationic oligopeptides on a DNA/RNA hybrid duplex. An oligopeptide containing the octamer of l-2,4-diaminobutyric acid (Dab8) was found to enhance both the RNase A resistance and RNase H activity of the DNA/RNA hybrid, which are important for developing nucleic acid drugs.
PMID: 30009294 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Hara RI, Maeda Y, Fujimaki H, Wada T Tags: Chem Commun (Camb) Source Type: research