The TRPM2 channel nexus from oxidative damage to Alzheimer's pathologies: an emerging novel intervention target for age-related dementia.

This article will review the emerging evidence from recent studies and propose a novel 'hypothesis' that multiple TRPM2-mediated cellular and molecular mechanisms cascade Aβ and/or oxidative damage to AD pathologies. The 'hypothesis' based on these new findings discusses the prospect of considering the TRPM2 channel as a novel therapeutic target for intervening AD and age-related dementia. PMID: 30009973 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30009973?dopt=Abstract

Source: Ageing Research Reviews - July 12, 2018 Category: Genetics & Stem Cells Authors: Jiang LH, Li X, Mortadza SAS, Lovatt M, Yang W Tags: Ageing Res Rev Source Type: research