Novel triazoles of 3-acetylbetulin and betulone as anticancer agents

AbstractThe CuAAC reaction of azides and acetylenic triterpenes was used for synthesis of new triazoles of 3-acetylbetulin and betulone. The triazole derivatives were evaluated for their anticancer activity in vitro against amelanotic melanoma C-32, ductal carcinoma T47D and glioblastoma SNB-19 cell lines. 28-[1-(3 ’-Deoxythymidine-5’-yl)-1H-1,2,3-triazol-4-yl]carbonylbetulone6e exhibited a significant IC50 value (0.17 µM) against the human glioblastoma SNB-19 cell line, an almost 5-fold higher potency while compared with reference cisplatin.

http://link.springer.com/10.1007/s00044-018-2213-x

Source: Medicinal Chemistry Research - July 17, 2018 Category: Chemistry Source Type: research