Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11 –dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome

Conclusions S1PR2 deficiency decreased macrophage pyroptosis and improved survival inE. coli sepsis. These beneficial effects were attributed to the decreased caspase-11 activation of S1PR2-deficient macrophages. S1PR2 and caspase-11 may be promising new targets for treatment of sepsis.
Source: Anesthesiology - Category: Anesthesiology Source Type: research