Genes, Vol. 9, Pages 357: Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake
Genes, Vol. 9, Pages 357: Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake
Genes doi: 10.3390/genes9070357
Authors:
Laura Liñares-Pose
Eva Rial-Pensado
Ánxela Estévez-Salguero
Edward Milbank
Ismael González-García
Claudia Rodríguez
Patricia Seoane-Collazo
Noelia Martinez-Sánchez
Rubén Nogueiras
Dolores Prieto
Carlos Diéguez
Cristina Contreras
Miguel López
Recent data have demonstrated that the hypothalamic GRP78/BiP (glucose regulated protein 78 kDa/binding immunoglobulin protein) modulates brown adipose tissue (BAT) thermogenesis by acting downstream on AMP-activated protein kinase (AMPK). Herein, we aimed to investigate whether genetic over-expression of GRP78 in the ventromedial nucleus of the hypothalamus (VMH: a key site regulating thermogenesis) could ameliorate very high fat diet (vHFD)-induced obesity. Our data showed that stereotaxic treatment with adenoviruses harboring GRP78 in the VMH reduced hypothalamic endoplasmic reticulum ER stress and reversed vHFD-induced obesity. Herein, we also demonstrated that this body weight decrease was more likely associated with an increased BAT thermogenesis and browning of white adipose tissue (WAT) than to anorexia. Overall, these results indicate that the modulation of GRP78 in the VMH may be a target against obesity.
Source: Genes - Category: Genetics & Stem Cells Authors: Laura Li ñares-Pose Eva Rial-Pensado Ánxela Estévez-Salguero Edward Milbank Ismael Gonz ález-García Claudia Rodr íguez Patricia Seoane-Collazo Noelia Martinez-S ánchez Rub én Nogueiras Dolores Prieto Carlos Di éguez Cristina Contreras Miguel L ó Tags: Article Source Type: research
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