c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/ β-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation

The proto-oncogene β-catenin drives colorectal cancer (CRC) tumorigenesis. Casitas B-lineage lymphoma (c-Cbl) inhibits CRC tumor growth through targeting nuclear β-catenin by a poorly understood mechanism. In addition, the role of c-Cbl in human CRC remains largely underexplored. Using a novel quantitative histopath ologic technique, we demonstrate that patients with high c-Cbl–expressing tumors had significantly better median survival (3.7 years) compared with low c-Cbl–expressing tumors (1.8 years; P = 0.0026) and were more than twice as likely to be alive at 3 years compared with low c-Cbl tumors (P =  0.0171).

Source: American Journal of Pathology - July 17, 2018 Category: Pathology Authors: Sowmiya Kumaradevan, Shin Yin Lee, Sean Richards, Chimera Lyle, Qing Zhao, Umit Tapan, Yilan Jiangliu, Shmyle Ghumman, Joshua Walker, Mostafa Belghasem, Nkiruka Arinze, Angela Kuhnen, Janice Weinberg, Jean Francis, Kevan Hartshorn, Vijaya B. Kolachalama, Tags: Regular article Source Type: research