Human Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers [Original Articles]
Conclusions:
EHT from hiPSC-CMs shows a lower repolarization reserve than human LV working myocardium and could thereby serve as a sensitive and specific human-based model for repolarization studies and arrhythmia, similar to Purkinje fibers. In both human LV and EHT, IKs only contributed to repolarization under adrenergic stimulation.
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Lemoine, M. D., Krause, T., Koivumaki, J. T., Prondzynski, M., Schulze, M. L., Girdauskas, E., Willems, S., Hansen, A., Eschenhagen, T., Christ, T. Tags: Arrhythmias, Electrophysiology, Basic Science Research, Ion Channels/Membrane Transport, Stem Cells Original Articles Source Type: research
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