Genetic and clinicopathologic characteristics of lung adenocarcinoma with tumor spread through air spaces

Lung adenocarcinoma is characterized by a broad range of histologic patterns and driver or targetable mutations [1,2]. The tumor invasion patterns in lung adenocarcinoma are also diverse compared with other organ cancers [1,3]. Tumor cell proliferation along the preserved alveolar structure is defined as ‘lepidic pattern’ and regarded as ‘non-invasive’ or ‘in situ carcinoma’ [1,3]. In contrast, non-lepidic patterns, such as acinar, papillary, micropapillary, or solid, are defined as ‘invasive,’ as is tumor infiltration into the stroma with desmoplastic reaction, which is a common inv asion pattern in other organ cancers [1,3].

Source: Lung Cancer - July 16, 2018 Category: Cancer & Oncology Authors: Jae Seok Lee, Eun Kyung Kim, Moonsik Kim, Hyo Sup Shim Source Type: research