Refining strategies to drive cognitive gains through transcranial electrical stimulation

Combining conventional non-invasive neuromodulatory therapeutics like Transcranial Magnetic Stimulation (TMS) or Transcranial Direct Current Stimulation (tDCS) with behavioral interventions like cognitive training, in a neuroscience-informed manner has the potential to harness cortical plasticity and thus deliver more robust therapeutic gains than either treatment delivered in isolation (Mehta, 2016). The application of such combinatory therapies is prominent in treating cognitive deficits and residual negative symptoms, which pose tremendous clinical challenges.
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research

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Publication date: Available online 21 February 2019Source: NeuroscienceAuthor(s): Guillermina Tellez-Merlo, Julio Cesar Morales-Medina, Israel Camacho-Ábrego, Ismael Juárez-Díaz, Patricia Aguilar-Alonso, Fidel de la Cruz, Tommaso Iannitti, Gonzalo FloresAbstractSchizophrenia is a severe mental disorder with numerous etiological susceptibilities. Maternal infection is a key risk factor for schizophrenia. Prenatal lipopolysaccharide (LPS) infection stimulates cytokine production that affects brain development. In the present study, we aimed to investigate the effect of prenatal LPS injection at gestation...
Source: Neuroscience - Category: Neuroscience Source Type: research
In this study, we describe the use of clozapine to treat 10 offenders with chronic, repetitive self-injury refractory to other medications and behavioral therapies. The primary diagnosis for all 10 offenders was a personality disorder. Eight of the 10 inmates allowed weekly blood draws and took medication regularly (approximately 95% adherence), whereas two inmates discontinued treatment within the first two weeks. For these eight patients, we compared the number of in-house urgent care visits and outside emergency room visits related to SIB for the six-month periods before and after treatment with clozapine. After initiat...
Source: Journal of the American Academy of Psychiatry and the Law - Category: Medical Law Tags: J Am Acad Psychiatry Law Source Type: research
ConclusionsThe current study found increased gamma oscillation in SZ and suggests significant involvement of the STG in gamma oscillations.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia, Published online: 22 February 2019; doi:10.1038/s41386-019-0350-7Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia
Source: Neuropsychopharmacology - Category: Neurology Authors: Source Type: research
In this study on the long-term use of antipsychotic polypharmacy in schizophrenia, researchers examined seven monotherapies and 22 antipsychotic combinations, excluding polypharmacy periods shorter than 90 days.Researchers analyzed data on all Finnish patients with schizophrenia treated in an inpatient setting from 1972 to 2014, and the 62,250 patients were followed for a median of 14 years, with researchers pulling data on their dispensation of antipsychotic medication. The primary outcomes studied were the number of psychiatric rehospitalizations, with hospitalizations due to physical illnesses and deaths serving as seco...
Source: Psychiatr News - Category: Psychiatry Tags: antipsychotics aripiprazole clozapine JAMA Psychiatry Jari Tiihonen monotherapy polypharmacy quetiapine rehospitalization schizophrenia Source Type: research
Authors: Lauriello J, Perkins DO Abstract Schizophrenia is a chronic disorder that can be effectively controlled but will likely require lifelong treatment. Unfortunately, most patients experience numerous relapses, ongoing symptoms, and impairment, often because of treatment interruptions. Continuous treatment is imperative to prevent relapse and the potentially devastating consequences that can follow a return of psychotic symptoms. Clinicians must better monitor a common cause of relapse, nonadherence, and offer strategies to improve adherence. Strategies can target the patient, the environment, or treatment. On...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Accelerated aging of cognitive networks after psychosis onset may offer the potential for early intervention in patients with schizophrenia or bipolar disorder, new research suggests.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news
Publication date: Available online 20 February 2019Source: Neurobiology of StressAuthor(s): Kimberly Wiersielis, Attilio Ceretti, Arron Hall, Sydney Famularo, Madeleine Salvatore, Alexandra S. Ellis, Harah Jang, Mathieu E. Wimmer, Debra BangasserAbstractStress can disrupt memory and contribute to cognitive impairments in psychiatric disorders, including schizophrenia and attention deficit hyperactivity disorder. These diseases are more common in men than in women, with men showing greater cognitive impairments. Mnemonic deficits induced by stress are mediated, in part, by corticotropin releasing factor (CRF). However, wher...
Source: Neurobiology of Stress - Category: Neuroscience Source Type: research
Yale researchers have created model thalamuses to study diseases like epilepsy, autism spectrum disorder, schizophrenia and depression.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
CONCLUSION: Dysregulation of hsa_circRNA_104597 may serve as a novel potential diagnostic and therapeutic biomarker for SZ. PMID: 30781971 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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