Refining strategies to drive cognitive gains through transcranial electrical stimulation

Combining conventional non-invasive neuromodulatory therapeutics like Transcranial Magnetic Stimulation (TMS) or Transcranial Direct Current Stimulation (tDCS) with behavioral interventions like cognitive training, in a neuroscience-informed manner has the potential to harness cortical plasticity and thus deliver more robust therapeutic gains than either treatment delivered in isolation (Mehta, 2016). The application of such combinatory therapies is prominent in treating cognitive deficits and residual negative symptoms, which pose tremendous clinical challenges.
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research

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Authors: Schürhoff F, Fond G, Berna F, Bulzacka E, Godin O, Boyer L, Misdrahi D, Andrianarisoa M, Brunel L, Coulon N, Aouizerate B, Capdevielle D, Chereau I, D'Amato T, Dubertret C, Dubreucq J, Faget C, Gabayet F, Mallet J, Rey R, Lancon C, Passerieux C, Schandrin A, Urbach M, Vidailhet P, Leboyer M, Llorca PM, FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group Abstract OBJECTIVES: The present article is a synthesis of the first 10 years of follow-up of the FondaMental Academic Center of Expertise for Schizophrenia (FACE-SZ) cohort. METHODS: More than 700 community-dwelli...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
Conditions:   Schizophrenia;   Schizo Affective Disorder Interventions:   Drug: D-serine;   Drug: Placebo Sponsors:   New York State Psychiatric Institute;   Nathan Kline Institute for Psychiatric Research Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Candice E. Crocker, Philip G. Tibbo
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
   When future NFL player Erik Coleman was eleven years old, he discovered that both of his parents were addicts (one to alcohol, one to harder drugs). This was a traumatic discovery, but made worse when, one day, he returned home from school to find his father had moved out. Erik shares this and more with us, including how this affected him as a child and as an adult, even through his years playing in the NFL. He shares his thoughts on what is most important for children of addicts to know, and of what happened to his parents later in life. Subscribe to Our Show! And Remember to Review Us! Show High...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction Family General The Psych Central Show Erik Coleman Gabe Howard Vincent M. Wales Source Type: blogs
We report specific changes in schizophrenia developmental interneurons by genome-wide transcriptome analysis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Reward processing and cognition are disrupted in schizophrenia (SCZ), yet how these processes interface is unknown. In SCZ, deficits in reward representation may affect motivated, goal-directed behaviors. To test this, we examined the effects of monetary reward on spatial working memory (WM) performance in patients with SCZ. To capture complimentary effects, we tested biophysically grounded computational models of neuropharmacologic manipulations onto a canonical fronto-parietal association cortical microcircuit capable of WM computations. Patients with SCZ (n = 33) and healthy control subjects (HCS; n = 32) performed a sp...
Source: Journal of Abnormal Psychology - Category: Psychiatry & Psychology Source Type: research
Previous research has revealed anticipatory pleasure deficits in people with schizophrenia and people with social anhedonia but who do not have schizophrenia. Prospection is an important component of anticipatory pleasure, but little is known about the role of prospection in social anhedonia. In 2 studies, we investigated prospection and anticipatory pleasure in people with schizophrenia and people with social anhedonia using an affective prospection task and a self-report measure, the Temporal Experience of Pleasure Scale (TEPS). In Study 1, we found that people with schizophrenia (n = 31) reported less TEPS anticipatory ...
Source: Journal of Abnormal Psychology - Category: Psychiatry & Psychology Source Type: research
While the at-risk for psychosis mental state approach to identifying emergent psychotic disorders has been catalytic in driving clinical research for youth populations, calls have been made to rethink the operationalisation of the construct (McGorry et al., 2018). The rationale for this is in part due to studies indicating a declining rate of transition to psychosis in recent years, reducing from around 40% in initial research, down to ~10% in more recent work (Morrison et al., 2012).
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research
The Brown University Child&Adolescent Psychopharmacology Update,Volume 20, Issue 11, Page 1-5, November 2018.
Source: The Brown University Child and Adolescent Psychopharmacology Update - Category: Psychiatry Source Type: research
CONCLUSION: Patients utilizing the LCC demonstrated high medication adherence, suggesting that injection services provided by the centers may reduce barriers to treatment and help patients with schizophrenia remain on LAI antipsychotic treatment. PMID: 30322282 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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