UCLA led the nation in organ transplants in 2017
Ronald Reagan UCLA Medical Center led the nation in the number of solid organ transplants performed in 2017, with 641 procedures that included kidney, pancreas, lung, heart and intestine transplants, according to statistics from the Organ Procurement and Transplantation Network.UCLA recorded 363 kidney transplants in 2017, making it the year ’s top kidney transplant center.Other medical centers with a high number of solid organ transplants in 2017 were UC San Francisco; Jackson Memorial Hospital in Miami, Barnes-Jewish Hospital in St. Louis, Missouri; and the University of Wisconsin ’s University Hospital in Madison.UCLA has also remained the overall transplant leader through for the first half of 2018, performing 360 solid organ transplants through June 30, according to the network ’s figures.In addition, UCLA performed the most kidney and liver transplants during the same six-month period, at 199 and 92, respectively.Dr. Ronald Busuttil, distinguished professor of surgery in the David Geffen School of Medicine at UCLA and chief of liver transplantation, lauded the team effort that has made UCLA the country ’s top transplant center.“None of this could have happened without the unwavering support and commitment of our multi-disciplinary transplant teams and leadership from our medical school and hospital,” he said.
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
This study aimed to investigate the effects of various perfusion temperatures on lung graft preservation during ex vivo lung perfusion (EVLP).
Cervical cancer is the most common gynecological cancer worlwide. Squamous intraepithelial lesions (SIL) are known precursors for carcinoma of uterine c èrvix and associated to infection by human papillomavirus (HPV). Several studies have shown an increased risk of malignant anogenital lesions in recipients of kidney and liver transplants compared to the general population, but there is less information in heart transplanted recipient
Right heart failure following left ventricular assist device implantation is one of the major challenges in patients suffering from advanced heart failure. There is still no ideal right-sided support system available. Here we describe the implantation of a stent valve at the inferior cavoatrial junction to protect liver and kidney during right heart failure.
The impact of opioid use in lung transplant (LTx) candidates on post-transplant outcomes is unknown. Previous studies on opioid therapy in kidney and liver transplant candidates have suggested increased risk of graft failure or death. We sought to test the association between pre-transplant opioid use in LTx candidates and overall retransplant-free survival.
The Model of End-Stage Liver Disease (MELD) score incorporates measures of kidney and liver dysfunction. MELD score has been shown to predict mortality in patients with advanced heart failure or cardiogenic shock (CS). Prior small single-center studies have shown that MELD score predicts mortality in patients supported with Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). The Purpose of our was to reassess the role of MELD score predicting Mortality After (VA-ECMO).
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Conclusions. Childhood transplant recipients have a 30 times greater cancer incidence versus the general population. Further investigation is needed to guide screening strategies in this at-risk population.
Publication date: Available online 16 February 2019Source: Social Science &MedicineAuthor(s): Athena EngmanAbstractThe concept of biographical disruption has now enjoyed nearly 40 years of use in medical sociology. This paper argues that taking an embodied approach to biographical disruption helps to explain the concept's enduring efficacy. Drawing on the work of Maurice Merleau-Ponty and contemporary theories of embodiment inspired by his phenomenology, this paper advances that biographical disruption involves, in the first instance, a disruption to the ability to enact an embodied orientation towards the world. Biogr...
Since the advent of lung transplantation, chronic lung allograft dysfunction (CLAD) has been the number one cause of long-term mortality.1 A subset of T cells, known as regulatory T cells (Tregs), have been shown to suppress inflammatory responses after organ transplantation. Much of what is known about the role of Tregs in suppressing alloimmune responses has come from experimental studies of kidney, heart, pancreatic islet, liver, and bone marrow transplantation. On the basis of these findings, 2 phase I clinical trials in which adoptively transferred Tregs were administered after kidney transplantation have been completed.