Breast Cancer Genetics and Indications for Prophylactic Mastectomy.

Breast Cancer Genetics and Indications for Prophylactic Mastectomy. Surg Clin North Am. 2018 Aug;98(4):677-685 Authors: Krontiras H, Farmer M, Whatley J Abstract As more genetic information becomes available to inform breast cancer treatment, screening, and risk-reduction approaches, clinicians must become more knowledgeable about possible genetic testing and prevention strategies, including outcomes, benefits, risks, and limitations. The aim of this article is to define and distinguish high- and moderate-risk breast cancer predisposition genes, summarize the clinical recommendations that may be considered based on the identification of pathogenic variants (mutations) in these genes, and indications for risk-reducing and contralateral prophylactic mastectomy. PMID: 30005767 [PubMed - in process]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Surg Clin North Am Source Type: research