Pulsed electromagnetic fields modulate bone metabolism via RANKL/OPG and Wnt/ β-catenin pathways in women with postmenopausal osteoporosis: A pilot study

Pulsed electromagnetic fields (PEMFs) have been proven to enhance in vitro and in vivo osteogenesis with unknown mechanism. Aim of our study was to explore whether RANKL/OPG and Wnt/ β-Catenin pathways could be involved in bone response to PEMFs in a setting of postmenopausal osteoporotic women.Forty-three women (mean age 62.8 ± 4.5 yr.) were randomized into two groups. The PEMFs group received PEMFs treatment (50 min treatment session/day, 6 treatment sessions/week, f or a total of 25 times), by wearing a specific gilet applied to the trunk and connected to the electromagnetic device (Biosalus, by HSD Srl, Serravalle RSM), while women assigned to control group received sham PEMFs with the same device.
Source: Bone - Category: Orthopaedics Authors: Tags: Full Length Article Source Type: research