Impact of aging on bone, marrow and their interactions

Hematopoiesis in land dwelling vertebrates and marine mammals occurs within the bone marrow, continually providing mature progeny over the course of an organism's lifetime. This conserved dependency highlights the critical relationship between these two organs, yet the skeletal and hematopoietic systems are often thought of as separate. In fact, data are beginning to show that skeletal disease pathogenesis influences hematopoiesis and viceversa, offering novel opportunities to approach disease affecting bone and blood.

Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Corey M. Hoffman, Jimin Han, Laura M. Calvi Tags: Review Article Source Type: research