Intestinal HIF-1 α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction

Alcoholic liver disease (ALD) ranges from hepatic steatosis to steatohepatitis, cirrhosis, and, potentially, hepatocellular carcinoma.1 While alcohol induces deleterious effects in the liver, it also disrupts gut microbiota homeostasis and intestinal epithelial integrity resulting in increased permeability, bacterial translocation and release of bacteria-derived endotoxin into the circulation.2 –4 Clinical and experimental studies have demonstrated that serum levels of lipopolysaccharide (LPS) are indeed increased in alcoholic individuals.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research