Emergence of unusual vanA/vanB2 genotype in a highly mutated vanB2-Vancomycin Resistant Hospital Associated E. faecium background, in Vietnam

Due to the clinical significance [1] and the capability to spread by cross-contamination leading to local outbreaks [2,3]. Hospital Associated-Vancomycin Resistance Enterococcus faecium (HA-VREf) is currently cause of increasing concerns, and was recently included in the seven “ESKAPE” nosocomial bacteria under global surveillance [4]. The HA-VREf originates from a specific Vancomycin Susceptible E. faecium (VSEf) subpopulation, characterized by Ampicillin Resistance (HA-AREf) [2,5] and the carriage of IS16 [6] insertion sequence which allows an enhanced genetic plast icity and an easier acquisition of mobile genetic elements (MGE), vehicles of antimicrobial resistance genes [7].

Source: International Journal of Antimicrobial Agents - July 15, 2018 Category: Drugs & Pharmacology Authors: Antonella Santona, Elisa Taviani, Hoa Minh Hoang, Maura Fiamma, Massimo Deligios, Tram Viet Q Ngo, An Van Le, Pietro Cappuccinelli, Salvatore Rubino, Bianca Paglietti Source Type: research