Reduced Microbial Diversity Is a Feature of Recessive Dystrophic Epidermolysis Bullosa-Involved Skin and Wounds

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disease characterized by epidermal fragility leading to chronic wounds (Fine et  al., 2014). RDEB is complicated by other pathologies such as esophageal strictures, anemia, mitten deformity, and corneal abrasion, but poor wound healing has arguably the greatest impact on quality of life and ultimately leads to the development of highly aggressive squamous cell carcinoma (Fine et al., 2009). One of the defining features of RDEB wounds is that when they do heal, they do so with evident scarring.

Source: Journal of Investigative Dermatology - May 10, 2018 Category: Dermatology Authors: Ignacia Fuentes, Christina Guttmann-Gruber, Angeline Su Ling Tay, Josefina Pi ñón Hofbauer, Simon L.I.J. Denil, Julia Reichelt, Francis Palisson, John E.A. Common, Andrew P. South Tags: Letter to the Editor Source Type: research