Effect of irradiation and bone marrow transplantation on angiotensin II- induced aortic inflammation in ApoE knockout mice

Angiotensin II (Ang II) infusion promotes the development of aortic aneurysms and accelerates atherosclerosis in ApoE −/− mice. In order to elucidate the role of hematopoietic cells in these pathologies, irradiation and bone marrow transplantation (BMT) are commonly utilized. The aim of this study was to investigate the effects of irradiation and BMT on abdominal and thoracic aortic aneurysm formation and acute leukocyte recruitment in the aortic root and descending aorta, an experimental mouse model of aortic aneurysm formation.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research