The intratumoral distribution influences the prognostic impact of CD68- and CD204-positive macrophages in non-small cell lung cancer

Lung cancer is the most common cause of cancer-related death worldwide, and non-small cell lung cancer (NSCLC) accounts for a majority of cases [1]. The precise prediction of the prognosis certainly leads to the better treatment of surgically resected NSCLC cases. One candidate method for determining the prognosis of resected NSCLC is the evaluation of infiltrating macrophages in tumors, which are generally known as tumor-associated macrophages (TAMs). TAMs are a key component of the cancer microenvironment that influence tumor growth and progression [2,3].

Source: Lung Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Zhuo Li, Daichi Maeda, Makoto Yoshida, Michinobu Umakoshi, Hiroshi Nanjo, Kouya Shiraishi, Motonobu Saito, Takashi Kohno, Hayato Konno, Hajime Saito, Yoshihiro Minamiya, Akiteru Goto Source Type: research