N1-methyladenosine methylome in messenger RNA and non-coding RNA.

N1-methyladenosine methylome in messenger RNA and non-coding RNA.
Curr Opin Chem Biol. 2018 Jul 09;45:179-186
Authors: Xiong X, Li X, Yi C
Abstract
Chemical modifications to rRNA, tRNA and mRNA provide a new regulatory layer of gene expression, which is termed as the `epitranscriptome'. N1-methyladenosine (m1A), first characterized more than 50 years ago, is a well-known modification in rRNA and tRNA. m1A in these abundant non-coding RNAs plays important roles in maintaining their biological functions. Recent studies also reveal that m1A is present in both nuclear-encoded and mitochondrial-encoded mRNA and is dynamically regulated by environmental and developmental conditions; m1A is found in a subset of nuclear-encoded long non-coding RNAs as well. Finally, we also discuss the potential challenges of identifying m1A modification in the human transcriptome.
PMID: 30007213 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - July 9, 2018 Category: Biochemistry Authors: Xiong X, Li X, Yi C Tags: Curr Opin Chem Biol Source Type: research