The role of IL-20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications.

The role of IL-20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications. J Leukoc Biol. 2018 Jul 12;: Authors: Chang MS, Hsu YH Abstract Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function. PMID: 29999545 [PubMed - as supplied by publisher]
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Tags: J Leukoc Biol Source Type: research