Effects of Sacubitril/Valsartan Versus Irbesartan in Patients with Chronic Kidney Disease: A Randomised Double-Blind Trial.

Conclusions -Over 12 months, sacubitril/valsartan has similar effects on kidney function and albuminuria to irbesartan, but has the additional effect of lowering blood pressure and cardiac biomarkers in people with chronic kidney disease. Clinical Trial Registration -URL: www.isrctn.com Unique Identifier: ISRCTN11958993.
PMID: 30002098 [PubMed - as supplied by publisher]

Source: Circulation - July 12, 2018 Category: Cardiology Authors: Haynes R, Judge PK, Staplin N, Herrington WG, Storey BC, Bethel A, Bowman L, Brunskill N, Cockwell P, Hill M, Kalra PA, McMurray JJV, Taal M, Wheeler DC, Landray MJ, Baigent C, UK HARP-III Collaborative Group Tags: Circulation Source Type: research