Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways

In conclusion, these results demonstrated that liquiritigenin attenuated HG-induced ECM accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways, suggesting that liquiritigenin might be a promising therapeutic agent for preventing the development of DN.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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This study was conducted on 1200 subjects aged>25 years. Hemoglobin from the above-mentioned subjects was detected using direct-infusion electrospray ionization-MS, and HbA1c and FPG were measured according to the manufacturer's instructions. Regression analysis was performed to estimate the correlations and interactions among HbA1c, FPG, and modified hemoglobin.ResultsMultiple modified forms (α1, α2, α3, β1, β2, and β3) of hemoglobin were observed using MS. Statistical analyses indicated that modified hemoglobin was significantly correlated with FPG (p ≤ .01). The association o...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Source: St. Michael's Hospital News and Media - Category: Hospital Management Tags: Hospital News Source Type: news
New research shows that up to 22 percent of people with diabetes who fasted for lab tests had a low blood sugar episode (hypoglycemia) while waiting for the test.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Publication date: Available online 10 December 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Shinje Moon, Hye Soo Chung, Jae Myung Yu, Hyung Joon Yoo, Jung Hwan Park, Dong Sun Kim, Yoo-Kyung Park, Sang Nam YoonAbstractObjectiveSelenium seems to be a risk factor for diabetes mellitus (DM) in recent studies, opposite to the previous expectation that it may contribute to prevent DM. The authors aimed to ascertain the relationship between selenium and DM.MethodsData were collected from the National Health and Nutrition Examination Survey conducted from 2011 to 2014. A multivariate logistic regression ...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
In conclusion, elucidation of different roles of subterminal HETEs in normal and disease states leads to identification of novel therapeutic targets and development of new therapeutic modalities in different disease states.
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Researchers report that impoverished communities in the U.S. have seen the fastest rise in diabetes and obesity during the last 30 years.
Source: Health News - - Category: Consumer Health News Source Type: news
Dr Peter Yellowlees discusses a new study which shows that two antipsychotics in particular may have negative metabolic effects.Medscape Psychiatry
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Psychiatry Commentary Source Type: news
ConclusionIn KSA, women who developed GDM, particularly those who are older, multigravid, and multiparous and who have a prior history of GDM, are at an increased risk of developing T2DM. Postpartum diabetes screening of patients with GDM within the recommended period need to be improved.
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
This study aimed to determine the predictors of discharge to a facility and develop and validate a predictive scoring model, utilizing the Oklahoma Trauma Registry (OTR).MethodsA multivariate analysis of the OTR 2005-2013 determined independent predictors of discharge to a facility. A scoring model was developed, and positive and negative predictive values (PPV and NPV) were evaluated for 2014 patients.Results101,656 patients were analyzed. The scoring model included age≥50 years, lower extremity fracture, ICU stay≥5 days, pelvic fracture, intracranial hemorrhage, congestive heart failure, cardiac dysrhythmia, histor...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Conditions:   Pre Diabetes;   Obesity Interventions:   Behavioral: Weight Loss;   Dietary Supplement: Egg Protein Sponsors:   Duke University;   Egg Nutrition Center Recruiting
Source: - Category: Research Source Type: clinical trials
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