Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways

In conclusion, these results demonstrated that liquiritigenin attenuated HG-induced ECM accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways, suggesting that liquiritigenin might be a promising therapeutic agent for preventing the development of DN.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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Publication date: September 2018Source: Advances in Medical Sciences, Volume 63, Issue 2Author(s): Małgorzata Wilusz, Dominik Cieniawski, Grzegorz Wasilewski, Marek Kuźniewski, Władysław Sułowicz, Krystyna SztefkoAbstractPurposeDiabetes mellitus and hyperlipidemia are frequently observed after organ transplantation. It is known that in these disorders the fatty acid metabolism is impaired. The aim of this study was to compare the fatty acid profile in the heart and renal transplant recipients who developed metabolic disorders since there is no such research available.Materials and methodsThe study included 55 patients...
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
Authors: Cai X, Wang L, Wang X, Hou F Abstract Insulin-like growth factor-binding protein 7 (IGFBP7) has been identified as a secreted protein associated with a number of cellular processes. However, the specific regulatory mechanisms of IGFBP7 on podocytes of diabetic nephropathy (DN) are yet to be elucidated. In the present study, podocytes were identified initially via an immunofluorescence assay using an anti-synaptopodin antibody. It was subsequently demonstrated that glucose promoted podocyte proliferation in a time- and dose-dependent manner via MTT assay. In addition, IGFBP7 expression was silenced in podoc...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
In conclusion, the data identified the IRE1α-Xbp1 signaling pathway as an essential mediator that associates EX-4 with the intracellular mechanism that inhibits ER stress and activates Akt in order to regulate β cell survival. This may provide important evidence for the use of EX-4 in treatments for type 2 diabetes. PMID: 30112049 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: Available online 17 August 2018Source: Journal of Visceral SurgeryAuthor(s): B. Le Roy, A. Dupré, A. Gallon, P. Chabrot, J. Gagnière, E. BucSummaryVarious procedures can promote hypertrophy of the future liver remnant (FLR) before major hepatectomy to prevent postoperative liver failure. The pathophysiological situation following portal vein embolization (PVE), hepatic artery ligation/embolization or hepatectomy remains unclear. On one hand, the main mechanisms of hepatic regeneration appear to be driven by hepatic hypoxia (involving the hepatic arterial buffer response), an increased portal...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
ConclusionsAlthough there was an acceptable correlation between the presence of subclinical atherosclerosis and SCOREM, there was a considerable proportion of atheromatous plaques in low-risk patients. Disease activity was the risk factor most closely associated with increased CVR.ResumenLa artritis reumatoide (AR) presenta una mortalidad de 1,3 a 3 veces superior a la población general; la principal causa de muerte son las complicaciones cardiovasculares (40-50%). En el abordaje inicial se debe incluir la valoración del riesgo cardiovascular (RCV) mediante algoritmos adaptados para esta población. Si ...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Authors: Mouslech Z, Somali M, Sarantis L, Christos D, Alexandra C, Maria P, Mastorakos G, Savopoulos C, Hatzitolios AI Abstract OBJECTIVE: Type 1 diabetes mellitus (T1DM) constitutes a real challenge in everyday practice for both physicians and patients. Due to the complexity of the disease and its unpredictable nature, structured education and training programs are nowadays implemented that ensure active patient involvement and self-care behaviors to achieve adequate glycemic control, prevent diabetic complications, and improve the quality of life of patients. These programs provide patients with the necessary kn...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Having a preference for evening activities, as well as sleeping at different times in the weekdays and weekends, may lead to weight gain in some people.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Diabetes Source Type: news
Publication date: Available online 17 August 2018Source: Neuroscience LettersAuthor(s): Yingli Jing, Mingming Liu, Fan Bai, Di Li, Degang YangAbstractPatients with spinal cord injury (SCI) have an increased risk for developing type 2 diabetes. It is unknown whether the pancreatic-islet microvascular vasomotion is involved. We used female C57BL/6 mice and a 100-kilodyne T10 Infinite Horizons contusion SCI (or T10 laminectomy) to detect blood glucose and pancreatic-islet microvascular vasomotion. Blood glucose obtained from tail vein was detected using one Touch UltraEasy glucometer. Glucose tolerance test was performed by D...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 17 August 2018Source: Life SciencesAuthor(s): Berenice Fernández-Rojas, Gloria Gutiérrez-VenegasAbstractFlavonoids are plant-derived polyphenolic compounds claimed to help alleviate a variety of conditions, including diabetes, infectious endocarditis, and cancer. They have attracted substantial research interest as nutraceuticals owing to their diverse bioactivities. Periodontitis is a high-incidence inflammatory disease affecting the dentition-supporting periodontium. Although the etiology of periodontitis is diverse, microbial species in dental plaque are considered its ma...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: January 2019Source: Biomedical Signal Processing and Control, Volume 47Author(s): Anirudh Nath, Rajeeb Dey, Carlos Aguilar-AvelarAbstractThis paper deals with the design of observer-based nonlinear control of blood glucose concentration (BGC) of Type 1 diabetes mellitus (T1DM) patients in a Linear Matrix Inequality (LMI) framework. The controller design relies on the information of the states obtained from a nonlinear observer. The control law is derived using feedback linearisation and regional pole placement technique. Further, a numerical optimisation method is proposed for the computation of the contr...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
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