Ethylenecarbodiimide-fixed splenocytes carrying whole islet antigens decrease the incidence of diabetes in NOD mice via down-regulation of effector memory T cells and autoantibodies.

In conclusion, ECDI-fixed splenocytes carrying whole islet antigens effectively prevented the onset of T1DM in NOD mice, via suppressing the production of autoantibodies and inducing anergy of autoreactive T cells. PMID: 29998909 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29998909?dopt=Abstract

Source: Endocrine Journal - July 14, 2018 Category: Endocrinology Tags: Endocr J Source Type: research