Fully-human Monoclonal Antibodies Against Human EphrinB2 and EphB4

Ephrin receptor tyrosine kinases and their ephrin ligands have been implicated in cancer pathogenesis. Ephrin receptors and ligands affect tumor growth, invasiveness, angiogenesis, and metastasis. Ephrin signaling activities in cancer are complex and are only now beginning to be uncovered. Researchers at the National Cancer Institute-Frederick, NIH developed a set of five fully-human monoclonal antibodies against human Ephrin-B2 and Ephrin type-B receptor 4 ( " EphB4 " ). The antibodies were identified by screening a naive human antibody phage display library against Ephrin-B2 and EphB4. These human monoclonal antibodies have high affinity and specificity for Ephrin-B2 and EphB4.IC: NCINIH Ref. No.: E-331-2008Advantages: High affinity and antigen specificityBind both soluble ectodomains and cell surface-expressed moleculesApplications: Research reagents for in vitro/in vivo investigation of Ephrin receptor and ligand interactionsTargeting reagents for in vivo imagingResearch reagents for protein co-crystallizationDevelopment Status: Discovery (Lead Identification)Updated On: May 30, 2018Provider Classifications: Publications: NCILicensing Contacts: Lead Inventor: LPM FIrst Name: JohnLPM Last Name: HewesInv Is lead: LPM Phone: [phone]LPM Email: [e-mail] Suffix: Ph.D.LPM Organization: NCI - National Cancer InstituteDTDT Classification: Research MaterialsDTDT Description:&...

Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research