Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics

The promise of RNA interference based therapeutics is made evident by the recent surge of biotechnological drug companies that pursue such therapies and their progression into human clinical trials. The present invention discloses novel RNA   and RNA/DNA nanoparticles including  multiple siRNAs, RNA aptamers, fluorescent dyes, and proteins. These RNA nanoparticles are useful for various nanotechnological applications. This technology has a higher detection sensitivity and higher silencing efficiencies of targeted genes than conventio nal siRNAs.  This technology has significant therapeutic potential against multiple disease types, including, cancer and viral infections.  Xxenograft mouse models indicated uptake of the nanoparticles, and six different HIV targets were validated with cell cultures.IC: NCINIH Ref. No.: E-765-2013Advantages: Potential for higher sensitivity, higher efficiency, low cytotoxicity, multiple functionality, multiple targets, and controlled activationApplications: Treatment for cancer and HIVDevelopment Status: Pre-clinical (in vivo)Updated On: Jun 18, 2018Provider Classifications: Publications: Patent Application: 15/022,530Patent Authority: US National StageLicensing Contacts: Lead Inventor: Inventor IC: NCIInventor Lab URL: https://irp.nih.gov/pi/bruce-shapiroLPM FIrst Name: JohnLPM Last Name: HewesInv Is lead: LPM Phone: [phone]LPM Email: John.Hew...

Source: NIH OTT Licensing Opportunities - July 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research