Regiodivergent copper catalyzed borocyanation of 1,3-dienes.

We report a regiodivergent process that allows a switch between 1,4-borocupration and 4,1-borocupration of 1,3-dienes upon a simple change in ligand. The subsequently generated allyl coppers are trapped in an electrophilic cyanation to selectively generate densely functionalized and synthetically versatile 1,2- or 4,3- borocyanation products.
PMID: 29992705 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - July 10, 2018 Category: Chemistry Authors: Jia T, He Q, Ruscoe RE, Pulis AP, Procter DJ Tags: Angew Chem Int Ed Engl Source Type: research