Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy.

Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy.
Chem Commun (Camb). 2018 Jul 12;:
Authors: Tian Y, Huang Y, Gao P, Chen T
Abstract
A negatively-charged and nucleus-targeted DNA tetrahedron is rationally designed and used as a nanocarrier of positively-charged metal complexes. This tetrahedron speeds up the translocation of metal complexes into the cell nucleus, and inhibits the growth and invasion of glioma cells by triggering vascular mimicry-associated signaling pathways, thus achieving precise glioma treatment.
PMID: 29998263 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 12, 2018 Category: Chemistry Authors: Tian Y, Huang Y, Gao P, Chen T Tags: Chem Commun (Camb) Source Type: research